Established in 1959, it contains numerous statues, tombs, columns and stone carvings from the Hellenistic, Roman, Byzantine, Seljuk and Ottoman periods, unearthed in ancient cities such as Alinda, Alabanda, Amyzon, Harpasa, Magnesia on the Maeander, Mastaura, Myus, Nisa, Orthosia, Piginda, Pygela and Tralleis.

The need of a new and bigger museum building became inevitable as the available space of the showrooms, warehouses and service units could not meet contemporary museology norms anymore.

[5] In addition, archaeological objects obtained from excavations at Alinda, Amyzon, Piginda, Harpasa, Mastaura, Acharaca, Pygale and Orthosia are also on display.

[2][6] This section contains artifacts from the Archaic Panionium Sanctuary at Melia on the top of Mycale located in Davutlar town of Kuşadası, Aydın.

[2][6] A small bronze Hittite statue is exhibited in a special showcase as an important find in addition to the terracotta pots and pans, stone axes and loom weights, all found during the excavations in a tumulus at Kadıkalesi in Kuşadası, Aydın.

[7] Furthermore, vitrified ornamental ceramics, jewellery, hilts, belt buckle, figures and reliefs of saints made of ivory dating back to 12th and 13th century as well as collection of lead seal prints from the Byzantine Era.

[2][6] In this hall, earthenware objects, oil lamps, glassware, golden crowns, diadems and various jewellery are on display, which were obtained from excavations at Alabanda near Doğanyurt, Çine in Aydın Province.

In addition, artefacts such as earthenware objects, oil lamps, rhytons, scent bottles, glassware, golden diadems, rings, earrings and various other jewellery as well as terracotta children's toys are on display.

The most important objects of the museum are small sculptures of Eros made of painted terracotta and a cremation urn decorated with incarnation motifs depicting destiny's gods Moirai, the soul of the dead person, chthonic god of the underworld Hades, the judges of the underworld and the three-headed guard dog Cerberus of Hades.

Other noteworthy objects are helmets depicted with the figure of Scylla, which is mentioned in Homer's Odyssey XII, Odysseus, statues of the Olympian gods Apollo and Hermes.

[2][6] Mosaics, discovered on the floor of a Roman villa from the 2nd century BC at the ancient city of Orthosia at Donduran village of Yenipazar, Aydın, consist of four main panels with borders made in opus tessellatum.