Ayerbe's main claim to fame is that Santiago Ramón y Cajal, winner of the 1906 Nobel Prize in Physiology or Medicine, lived here for ten years.

The town promotes his memory with a museum and visitor centre; Ayerbe library holds a collection of Cajal-related books with more than 250 works and documents for public use.

Ayerbe has a public library, casino, bars, municipal swimming pool and, around the town, a network of footpaths, fields and highways for walkers and cyclists.

There are several restaurants, a hotel and bed and breakfast accommodation, as well as tourist information center in the summer months in one of the town squares.

"The week of the mushrooms" has been celebrated in the town for years in the month of October and constitutes a social event on an international level.