[4][5] After making her debut with Tum Jo Miley in 2009, Khan garnered recognition through her roles in Pyarey Afzal (2013), Mere Meherbaan (2014), Tum Kon Piya (2016), Mohabbat Tumse Nafrat Hai (2017), Tau Dil Ka Kia Hua (2017), Koi Chand Rakh (2018) and Chupke Chupke (2021).
[6] Khan further received critical praise her portrayal of Mehwish in Mere Paas Tum Ho (2019) and won the Pakistan International Screen Award for Best TV Actress.
[14][15][16] Her performance in the 2019–20 romantic drama Meray Paas Tum Ho[17] earned her Pakistan International Screen Award for Best Television Actress.
[18] In 2023, her performance in Bafar Mehmood's dramatic Mein[19] opposite Wahaj Ali in which, she portrayed as an egoistic lady with bipolar disorder was panned by critics and audiences.
In 2023, now she is also portraying as an headstrong and kind women in Jaan-e-Jahan[20] opposite Hamza Ali Abbasi in their second project together after Pyaray Afzal.
[24][25] Khan married actor Danish Taimoor in 2014,[26] after an 8-year relationship since 2006, shared by the couple in a morning show Ek Nayee Subha with Farah on A-Plus.
[27][16] Taimoor, while talking to Maria Wasti at Croron Mein Khel-Bol TV on 25 March 2020, revealed that he met Ayeza Khan for the first time on social networking site.