He is considered to be one of the greatest artists in the history of Bangladeshi folk music and a founding figure of Bangla rock.

He took part in the 1969 mass uprising against the Pakistani military, which resulted in the resignation of Pakistan's president, Ayub Khan among other concessions to protesters.

This was followed up with more hit songs in the 1970s, like "Alal ar Dulal", "Saleka Maleka" and "Papri Keno Bojhena".

He enrolled in T & T College in 1970, but his studies were interrupted by his participation in the Liberation War alongside his father and siblings.

At the age of 21, he and two friends traveled to Agartala on foot with the goal of serving under major Khaled Mosharraf in Sector 2.

Khan served under section commander Khaled Mosharraf on a guerilla team known as Crack Platoon.

His section managed to defeat members of the Pakistani army in a battle organized in Trimohani, near Madartek.

The program was directed by Mansur Ahmed Nipu of Spandan and produced by Noazesh Ali Khan of BTV.

Some of his biggest hits are "Ore Saleka, Ore Maleka", "Jibone Kichhu Pabona Re", "Ami Jare Chaire", "Ashi Ashi Bole Tumi", "Obhimani", "Rail liner bostite", "Hei Allah Hei Allah Re", "Alal O Dulal".

[15][16] Khan, along with his contemporaries Fakir Alamgir, Ferdous Wahid, Pilu Momtaz, Firoz Shai and Nazma Zaman is credited with pioneering popular music in Bangladesh.

[17] About his career, pop singer Habib Wahid said, "the history of Bangladeshi rock music began with Azam Khan.

"[18] His influences included famous Indian singers such as Kishore Kumar, Hemanta Mukherjee, Manna Dey, as well as British rock bands The Beatles and The Rolling Stones.

He was particularly intrigued by George Harrison, whose 1971 Concert for Bangladesh sought to rally support for the liberation army in the West.