De Regil debuted on television in the telenovela Bajo el alma.

[2] On November 5, 2020, it was reported that she had joined the cast of the crime action film Blackout opposite Josh Duhamel, Abbie Cornish, Nick Nolte and Omar Chaparro.

[3] In April 2021, De Regil was cast in the lead role of the romcom television series Parientes a la fuerza on Telemundo, the Spanish-language network subsidiary of NBC Universal.

[6] She is the cousin of Mexican broadcaster and presenter Marco Antonio Regil.

[8] In 2017, she married attorney and real estate developer Fernando Schoenwald.