Bøstrup was created in 1600 by royal treasurer Henrik Müller through the merger of two smaller farms at the site.

Shortly thereafter, Anna Catharine Müller bought her sister's share of the estate.

In 1631, one year after her husband's death, Else Batholin (née Berg) married one lieutenant-colonel Ventin.

His widow sold Bøstrup to Laurids Svitser, who also increased the size of the estate through the acquisition of more land.

He was succeeded by his son, Emil van Deurs, who improved the soil quality, merged farms and transformed the copyholds to freeholds.

The central main wing is built of brick from the estate's own brickyard and features a median risalt tipped by a triangular pediment.

[2] In 1881, Christian Hansen added a median risalit on the other side of the main wing as well as a veranda overlooking the garden.