His best-known and most critically acclaimed work is Vishnupuram, a fantasy set as a quest through various schools of Indian philosophy and mythology.

In 2014, he started his most ambitious work Venmurasu, a modern renarration of the epic Mahabharata and successfully completed the same, thus creating the world's longest novel ever written.

[1] His other well-known novels include Rubber, Pin Thodarum Nizhalin Kural, Kanyakumari, Kaadu, Pani Manidhan, Eazhaam Ulagam and Kotravai.

The suicide of a close friend drove him to drop out of college and constantly travel the country in search of physical and spiritual experience.

The novel won the Akilan Memorial prize for its path-breaking portrayal of the ecological and sociological impact of rubber cultivation in the South Indian states of Kerala and Tamil Nadu.

Jeyamohan's speech at the awards function was well received, and he further developed those ideas in Novel (1990), an exploration of the art form and its ideologies, and Naveena Thamizhilakkiya Arimugam, a comprehensive introduction to modernist Tamil literature.

His experiences convinced him of the continuing relevance of Gandhian idealism and non-violence as the sensible alternative to naked capitalism and militant socialism.

The leftist in him had been saddened by the collapse of the Soviet Union in 1991, and a decade long introspection on the nature of power and self-righteousness found expression in Pin Thodarum Nizhalin Kural in 1999.

In parallel, Jeyamohan has produced a prolific output as one of the foremost Literary critics and theorists of modern Indian literature with focus on Tamil.

[9] Jeyamohan had been an active participant in Tamil internet discussion groups like Mayyam, Forumhub and Thinnai.com during the early years of the medium in India.

As a part of the series, he sought to explain how the next generation of Gandhian leaders like Anna Hazare were continuing to inspire the nation towards achieving true democracy and equality.

Rather than focus on the minutiae of the bill itself, Jeyamohan focused readers' attention on the ideology behind Hazare's actions – how he appealed directly to the sense of justice in the common man, his symbolism, and the Gandhian method of achieving the ultimate goal through civil non-violent mass movement without letting up any opportunity to discuss and negotiate with political opponents.

Amidst widespread scepticism and slander flamed up by the national and regional media across the political spectrum, Jeyamohan remained rock solid in support of Anna Hazare's movement.

[11] In 2016, on the occasion of state elections in Tamil Nadu, Jeyamohan wrote a series of essays on Democracy in the newspaper Dinamalar which was published as a book.

Krishnamurthy (veterinarian) ('Dr K, the Elephant Doctor') sparked huge interest and discussion among readers on the impact of humans on forest life.

In early 2008, Jeyamohan satirical articles on Tamil movie icons M G Ramachandran and Sivaji Ganesan were published by popular print weekly, Ananda Vikatan.

According to The Hindu, the police reported that a female store staff refused to take the batter back from Jeyamohan after he claimed it to be spoilt.

[18] In 2024, Jeyamohan’s blog post on the film Manjummel Boys kicked up controversy over several comments that he made on Malayalam cinema and Malayalis.

The post said that the film, based on a real-life survival story involving a group of young Malayali friends visiting the Guna Caves in Kodaikanal, where one of them slips and falls into a deep hole, was "nothing but a celebration of ‘porikkis’ (loafers), justifying their drunken deeds and normalising drug abuse", like much of Malayalam cinema.