The story focuses on the salacious wishes of a high school girl, whose perceived drawback of being a virgin leads to her lusting after and pursuing a rather average and unremarkable boy in her class.

B Gata H Kei follows lascivious 15-year-old high school student Yamada, who makes it a goal to have sexual relations with 100 different guys, although her insecurities as a virgin herself lead her to reject every chance to do so.

She makes a rather plain classmate of hers, Takashi Kosuda, the target of her seductions for the sole purpose of achieving this goal; however, she ultimately falls for him.

[29] Funimation licensed the series with the title Yamada's First Time: B Gata H Kei, and released it on DVD and Blu-ray on January 31, 2012.

[34] It fared well in an ANN review of the Complete Series Collection, Rebecca Silverman commented that although it was a "bit tasteless" it is "also a surprisingly clean, very funny show about one girl's realization that sex and emotion aren't totally divorced from each other.

The team responded that the studio and its writers are not solely responsible for the content, the anime was handled by the production committee, and that they have reported the threats to the police.