[3] The row house on 216 Emory Street in Ridgely's Delight, Baltimore, was leased by Pius Schamberger, Ruth's maternal grandfather.

However, Hirsh Goldberg, the press secretary for Baltimore Mayor Theodore McKeldin, successfully campaigned to save and restore the Birthplace.

Ruth's widow, Claire, his two daughters, Dorothy and Julia, and his sister, Mamie (also born in 216 Emory Street), helped select and install exhibits for the museum.

[5] In 2015, renovations were undertaken with improved accessibility for disabled people, re-imagined galleries, repairs on decaying woodwork, as well as the addition of an entrance on Dover Street.

The museum reopened to the public during the week both the New York Yankees and Boston Red Sox, Ruth's affiliated teams, were visiting Camden Yards to play the Orioles.