The event aired via pay-per-view (PPV) and livestreaming and featured wrestlers from the promotion's Raw and SmackDown brand divisions.

Puerto Rico native and Grammy Award winning rapper Bad Bunny was featured at the event.

In other prominent matches, Austin Theory defeated Bobby Lashley and Bronson Reed to retain the United States Championship, Rhea Ripley defeated Zelina Vega, who was WWE's only female roster member of Puerto Rican descent, to retain the SmackDown Women's Championship, and in the opening bout, Bianca Belair defeated Iyo Sky to retain the Raw Women's Championship, subsequently becoming the title's longest-reigning champion.

The event received positive reviews, with fans and critics lauding the San Juan Street Fight and the Raw Women's Championship match, deeming them highlights of the night, while also praising Rollins vs. Omos, the six-man tag team match, and the main event.

The event featured wrestlers from the Raw and SmackDown brand divisions, and aired on pay-per-view (PPV) worldwide and was available to livestream on Peacock in the United States and the WWE Network in most international markets.

[6] It was initially announced that Grammy Award winning Puerto Rican rapper Bad Bunny would serve as the host of Backlash.

He had previously performed his song, "Booker T", at the 2021 Royal Rumble, wrestled in a couple of matches, and also won the now-defunct WWE 24/7 Championship.

[16] On April 17, a six-man tag team match pitting The Bloodline (The Usos and Sikoa) against Riddle, Zayn, and Owens was scheduled for Backlash.

[17] In the main event of Night 2 of WrestleMania 39, Roman Reigns defeated Cody Rhodes to retain the Undisputed WWE Universal Championship after interference from Paul Heyman and Solo Sikoa.

[15] It was later reported that Lesnar was irate due to his position on the WrestleMania card, as his match had opened Night 2 instead of the main event slot.

[20] In mid-March, Legado Del Fantasma (Santos Escobar, Cruz Del Toro, Joaquin Wilde, and Zelina Vega) began assisting Rey Mysterio in his rivalry with The Judgment Day (Finn Bálor, Damian Priest, Dominik Mysterio, and Rhea Ripley).

[21] This partnership eventually resulted in Rey reforming the Latino World Order (LWO) with Legado del Fantasma.

[22] On the April 14 episode of SmackDown, during a match between Escobar and Priest, Ripley attempted to interfere only to be thwarted by Vega.

[16] The following week, Vega asked WWE official Adam Pearce for a match against Ripley for the SmackDown Women's Championship at Backlash.

[23] At WrestleMania SmackDown on March 31, Bobby Lashley won the André the Giant Memorial Battle Royal by last eliminating Bronson Reed.

[19] The following week, Lashley faced United States Champion Austin Theory in a non-title match, which ended in a no contest after Reed interfered.

[20] On April 21, it was announced that Theory would defend his title against Lashley and Reed in a triple threat match at Backlash.

[15] On the April 24 episode, Bad Bunny returned and announced that although he was originally to be the host of Backlash, he would instead be facing Priest in a San Juan Street Fight at the event.

[1] After that, Austin Theory defended the United States Championship against Bobby Lashley and Bronson Reed in a triple threat match.

[1] In the fourth match, Rhea Ripley defended the SmackDown Women's Championship against Zelina Vega, WWE's only female wrestler of Puerto Rican descent.

Bunny came out to his single "Chambea" and paid homage to Extreme Championship Wrestling wrestler New Jack by pushing a shopping cart full of weapons to the ring.

Former WWE Puerto Rican wrestler Carlito made a surprise return (his first appearance since the February 1, 2021, episode of Raw) and drove Bálor and Dominik out of the ring.

Dominik and Bálor attempted to escape only for another former Puerto Rican WWE wrestler, Savio Vega, to make his return (his first appearance since the 2020 Survivor Series), followed by the Latino World Order (LWO) (Santos Escobar, Cruz Del Toro, and Joaquin Wilde) and they drove Bálor and Dominik out from ringside.

Following the match, Bad Bunny celebrated by displaying the Puerto Rican flag with the LWO, Carlito, and Vega.

The event received acclaim, with particular praise for the San Juan Street Fight and the Raw Women's Championship bout.

Paul Heyman then revealed that instead of The Usos, Reigns and Sikoa would challenge Kevin Owens and Sami Zayn for the Undisputed WWE Tag Team Championship at Night of Champions.