[6] The immediate objective of the hospital was to help cure epidemics and common diseases specifically affecting the ethnic Greek population of Constantinople.

[6] By the end of the 18th century, the Greek community of Constantinople had built three hospitals: this one, in 1762 another in the district of Galata and in 1780 a third in Pera.

During the Istanbul riots of 1955, the hospital received many patients, who suffered from trauma, rape, and physical abuse.

[8] The hospital was restored in 1991 and in 1994, the first private clinic for the treatment of alcohol and substance abuse in Turkey was established.

In August 2002, a new law was passed by the Turkish parliament to protect the minorities rights, because of Turkey's EU candidacy.