[5] Because of the changes in how the bones of the skull are connected together, people with BGS will have an abnormally shaped head, known as brachycephaly.

[5] Radial ray deficiency is another clinical characteristic of those with BGS, and results in the under-development (hypoplasia) or the absence (aplasia) of the bones in the arms and the hands.

[1][6] Oligodactyly can also result from radial ray deficiency, meaning that someone with BGS may have fewer than five fingers.

[5] Radial ray deficiency that is associated with syndromes (such as BGS) occurs bi-laterally, affecting both arms.

Adults may pursue genetic counselling to understand the syndrome, as well as the risks and choices regarding family planning.

Surgery shortly after birth can repair craniosynostosis, as well as defects in the hand to create a functional grasp.