Baltazar Leite Rebelo de Sousa, GCIH (16 April 1921 in Lisbon, Santos o Velho – 1 December 2001 in Lisbon) was a Portuguese politician and a former minister and member of parliament and medicine professor.

He then became secretary of state and minister of the corporations and health, deputy to the Assembly of the Republic (Assembleia Nacional), vice-president of the Overseas Council, vice-president of the Acção Nacional Popular, Governor-General of Mozambique from 1968 until 1970, and finally the last Minister for the Overseas before the Carnation Revolution.

In its aftermath, he went to his ministry where he stood most part of the day and communicated with the rest of the Portuguese Council of Ministers, who were seized in Quartel do Carmo (a military facility in Lisbon).

He also had an active role in Luso-Brazilian associacions, such as the Associação Luso-Brasileira, of which he became the director, also being a member and president of the Curator Council of the Fundação Luso-Brasileira para o Desenvolvimento dos Países de Língua Portuguesa.

He married in Lisbon in 1941 or thereabouts, in a simple ceremony with only two of his friends as witnesses, in a union not approved by both parents at the time, to Maria das Neves Fernandes Duarte (Covilhã, Conceição, 30 July 1921 – Lisbon, 8 March 2003), daughter of Joaquim das Neves (b. Covilhã, Erada, 1 January 1874) and wife Maria Rosa Fernandes Duarte (b. Covilhã, 1889?