Ghosh was born in Mymensingh in present-day Bangladesh, her father Prafulla Krishna Ghose was also a musician and poet, and editor of a children's magazine.
[1] She was trained in Hindustani classical music and at Shantiniketan with the noted Rabindra Sangeet exponent Kanika Banerjee.
With a formal degree in music from Rabindra Bharati University, she also trained with Dilip Kumar Roy of Pondicherry.
Bursting into the Rabindrasangeet scene in the 1970s, she quickly rose to become an eminent Rabindra Sangeet artist on All India Radio and Doordarshan.
Subsequently, Ghosh lived in Switzerland and in the United States, where she ran Antara, a Rabindrasangeet organization that has trained thousands of pupils across the USA over the years.