Banate of Lugos and Karánsebes (Hungarian: Karánsebesi-Lugosi bánság, Romanian: Banatul de Lugoj-Caransebeș, Serbian: Лугошка и карансебешка бановина, romanized: Lugoška i karansebeška banovina) was an administrative and territorial entity (banate) of the Eastern Hungarian Kingdom and the Principality of Transylvania.

The banate was organized as a militarized border area, created in order to defend the region from the advancing Ottoman Empire.

Centered in cities of Lugoj and Caransebeș, it was encompassing the south-eastern part of the modern region of Banat, inhabited in those times by Hungarians, Romanians and Serbs.

Its eastern side, from Orsova (present-day Orșova), came under the jurisdiction of the Wallachian ruler.

In 1658, the new Prince of Transylvania, Ákos Barcsay [hu; ro], ceded the region to the Ottoman Empire.