The Bangladesh cricket team toured South Africa in March and April 2022 to play two Tests and three One Day International (ODI) matches.

[7][8] Bangladesh won the first ODI by 38 runs,[9] recording their first win against the hosts in an international cricket match in South Africa.

[20] On the morning of the fourth day of the second Test match, Sarel Erwee and Wiaan Mulder were replaced by Glenton Stuurman and Khaya Zondo as COVID-19 substitutes.

[32] During the first Test, the BCB confirmed that both Taskin Ahmed and Shoriful Islam would return home to Bangladesh following the conclusion of the match due to injuries.

[34] As a result, South Africa named a weakened squad for the Test matches,[35] with Marco Jansen, Aiden Markram, Lungi Ngidi, Anrich Nortje, Kagiso Rabada and Rassie van der Dussen all playing in the IPL.