Native to regions spanning from the East to the Midwest of North America, Baptisia species contribute to the natural beauty of various ecosystems.

[2] Renowned for their resilience, Baptisia species can endure high heats, drought periods, along with notable resistance to diseases.

[13] A tea, made from the leaves and stalks, was used to treat snake bites, as it has astringent and antiseptic properties, as well as to counteract mercurial salivation.

[15] The tea was also applied topically to alleviate leg, arm, and stomach cramps and wounds, with additional claims of stimulating bile secretion.

German studies have demonstrated that extracts from the plant stimulate the immune system, although caution is advised regarding large doses due to potential harm.

[13] During the early 19th century, the U.S. Pharmacopeia included wild indigo, as doctors experimented with extracts derived from the plant to treat typhoid fever.

Experimental use of root tinctures and powders resulted in symptoms resembling those of the onset of typhoid, leading practitioners of homeopathy to anticipate potential cures for the disease.