The series features voice roles from a Filipino ensemble cast: including Migo Adecer, Julie Anne San Jose, Ruru Madrid, Kelley Day, John Arcilla, Edu Manzano, and Cherie Gil.

[4][5] Two years before the start of the series, Roberto "Coach B" Sebastián, Sr.'s son, Roberto "Basti" Sebastián Jr., was killed by a gunman from a large syndicate which brought down the Barangay 143's Powerhouse team and led to today's events.

[9] TV Asahi is responsible for Barangay 143's direction as well as coming up with character designs for the series.

[10][11] A Comeback GMA Network Sylvia Sanchez to voice Kapitana Baby Dela Cruz but replaced by actress Lorna Tolentino.

It is described by the producers as a "360-degree concept" and a story of love, hubris, drama, crime and basketball.

[15] Barangay 143 is primarily targeted towards the youth/young-adult market of the Philippines and is planned to be released in other Southeast Asian countries as well.

[22] In October 2016, August Media Holdings announced that a subscription game with a telecommunications company will be launched soon.