[4] In 2009, Keenan asked to be considered for a seat on the United States Court of Appeals for the Fourth Circuit.

On June 2, 2009, Virginia's senators recommended that President Barack Obama nominate her to the Fourth Circuit.

[8] On February 26, 2010, Senate Majority Leader Harry Reid filed for cloture on Keenan's nomination.

[4] In Seay v. Cannon, on June 21, 2019, Keenan, who was joined by A. Marvin Quattlebaum Jr., ruled that double jeopardy bars retrial after a mistrial is granted over a defendant's objection.

[11] On March 30, 2020, the Supreme Court denied certiorari, although Justices Thomas, Alito, and Kavanaugh would have granted cert to the case.

[12] Keenan strongly dissented in part in an August 9, 2021 decision which ruled that a charter school's policy to force female students to wear dresses or skirts did not violate Title IX, despite allowing the Title IX lawsuit to continue.

Women serve on our country’s Supreme Court, in Congress, and, today, a woman is Vice President of the United States.