During her time in office, she notably oversaw the entry into force of a French tax targeting palm oil and a ban on neonicotinoids in 2016.

[7] She was reelected in the 2017 legislative election and subsequently served as chairwoman of the Sustainable Development, Spatial and Regional Planning Committee from 2017 until 2020.

[13] In October 2023, Pompili was appointed to the General Secretariat for Ecological Planning (SGPE), serving as President Macron's Special Envoy for the 2024 One Water Summit.

[14] In July 2019, Pompili decided not to align with her parliamentary group's majority and became one of 52 LREM members who abstained from a vote on the French ratification of the European Union’s Comprehensive Economic and Trade Agreement (CETA) with Canada.

[15] She also defended amendments on the transparency and labeling of genetically modified organisms used in food products in defiance of the government's advice, as well as opposed delays in the country's strategy to reduce pesticides use and the phase-out of glyphosate.