Barker House is a historic home located at Edenton, Chowan County, North Carolina.

It is a 2+1⁄2-story frame dwelling with Georgian, Federal, and Greek Revival style design elements.

The front facade features a full-length, two-tier porch carried on superimposed fluted pillars under a shed roof.

The house commemorates the life of Penelope Barker of Edenton who organized 51 ladies to sign a petition to King George III saying NO to taxation on tea and cloth.

This article about a property in Chowan County, North Carolina on the National Register of Historic Places is a stub.