It was created first in 1801 as a substantive title by King George III for his son Prince Augustus Frederick.
Although Prince Augustus Frederick was survived by a son and daughter by Lady Augusta Murray, their marriage (purportedly solemnized at St George's Hanover Square Church, Westminster, in 1793) had been annulled for lack of royal permission under the Royal Marriages Act 1772, rendering the children illegitimate under English law and unable to inherit titles from their father.
Both children by the annulled marriage died childless, rendering the issue of their inheritance moot.
On 2 May 1831, Prince Augustus Frederick married secondly (and again in contravention of the Royal Marriages Act 1772), Lady Cecilia Gore at Great Cumberland Place, London.
[2] The second creation in 1881, as a substantive title by Queen Victoria for her son Prince Leopold.