His father Sir George had supported English colonization of the North American territories, and his younger brother, Leonard Calvert (1606–1647, ruled 1634–1647), traveled across the Atlantic Ocean to become the first colonial Governor of Maryland.

In 1705, the 4th Baron sold to the Crown a house and gardens (owned by virtue of his wife) known as Woodstock Park, which was promptly demolished and replaced by Blenheim Palace, a site regally granted to the victorious Duke of Marlborough as a gift.

[4] It swiftly became the only private mansion termed a palace in England; however, this loss was partially recouped when the 4th Baron inherited an additional manor house and farm in Epsom, Surrey, on the death of his distant cousin Lady Ann(s) Lewknor (née Mynne), his father having already owned, since 1692, from the death of Elizabeth Evelyn (née Mynne), a mid-17th century-built neighbouring fine house known as Woodcote Park.

On the Avalon Peninsula in the Province of Newfoundland and Labrador of the northeastern Dominion of Canada, there is a settlement named Calvert, and in nearby Ferryland there is a "Baltimore School".

A life-sized bronze statue on a granite pedestal of Cecil, 2nd Lord Baltimore (1605–1675), is located on the steps of the western end at the St. Paul Street entrance of the Baltimore City Circuit Court House, the third courts structure on the nearby colonial-era Courthouse Square site (located to the east along North Calvert Street), constructed 1896–1900 (now renamed the Clarence M. Mitchell Jr.

This Union Jack canton is in the upper corner of the banner over the black and gold (yellow) chevrons depicted on the Calvert family's shield and coats-of-arms.