Wilhelmine was the daughter of the former Prussian Vice President and Director of the royal chamber of Brandenburg-Ansbach, Baron Ernst Heinrich Konrad Friedrich von Dörnberg (1769-1828) and his wife Baroness Wilhelmine Sophie Henriette Maximiliane von Glauburg (1775-1835).

Wilhelmine married Maximilian Karl, 6th Prince of Thurn and Taxis, fourth child of Karl Alexander, 5th Prince of Thurn and Taxis and his wife Duchess Therese of Mecklenburg-Strelitz, on 24 August 1828 in Regensburg.

Despite the fierce resistance to the union from the members of the princely house, especially from Maximilian Karl's mother Therese, the two married.

[2] In 1834, Wilhelmine fell ill on a hard drive to Castle Chraustowitz, one of the many estates that Thurn and Taxis family possessed in Bohemia.

Wilhelmine was hopeful that the treatments would restore her quality of life.