Barranca de Metztitlán is a biosphere reserve in the Mexican state of Hidalgo.

It is protected for its dramatic scenery of steep cliffs and deep winding canyons, and its distinctive flora and fauna.

It is part of the Panuco River system, which drains into the Gulf of Mexico.

[3] It lies in the municipalities of Acatlán, Atotonilco El Grande, Eloxochitlán, Huasca de Ocampo, Metztitlán, San Agustín Metzquititlán, Metepec, Zacualtipán, and Cardonal.

[2] The Barranca de Metztitlán was designated a national biosphere reserve on 27 November 2000 by presidential decree.