[6][7] Weed made her Broadway debut in Lysistrata Jones in November 2011, as an understudy for many of the female roles.

Previews began on November 19, 2012, with an official opening on December 9, 2012, and the show ran through February 3, 2013.

The musical premiered at Hudson Backstage Theatre in Los Angeles in the fall of 2013, before moving to New York for its Off-Broadway incarnation.

[11] Weed played the role of Sally Bowles in the Signature Theatre production of Cabaret from May 12 to June 28, 2015, in the Washington, D.C.

[12] For this performance, she won the Helen Hayes Award for Outstanding Lead Actress in a Musical.

The musical, based on the film of the same name began previews on Broadway on March 12, 2018, and officially opened April 8, 2018.

On December 2, 2020, it was announced that Weed joined the cast of Bridge and Tunnel, a TV show on Epix.

She plays Lizzie, "the artsy, sarcastic older sister of Pags (Brian Muller), who dreams of rock stardom for her all-girl punk band, Wildfire".

[20][21] Weed is an advocate for a number of causes, including female empowerment, gun control, and voting rights.