Scheck is the director of the Innocence Project and a professor at Yeshiva University's Benjamin N. Cardozo School of Law in New York City.

He was associated with the clearing in 1999 of Dennis Fritz and Ron Williamson who had spent 11 years in prison of wrongful murder convictions.

[7] However, Vincent Bugliosi,[8] Darnel M. Hunt,[9] Daniel M. Petrocelli,[10] and defense witness Henry Lee all wrote that Scheck made many factually false claims about the physical evidence.

[11] Lee wrote in Blood Evidence: How DNA is Revolutionizing the Way We Solve Crimes (2003) that both of the defense's forensic DNA experts, Lee and Edward Blake, had rejected Scheck's argument that the mistakes made during evidence collection rendered the results unreliable and his contamination claim.

[12][13] Hunt wrote in O. J. Simpson Facts and Fictions: News Rituals in the Construction of Reality that Scheck "floated ridiculous conspiracy theories to the jury".

Simpson that "Scheck's arguments presupposed a conspiracy so immense within the LAPD that, analyzed objectively, it seemed a practical impossibility.

Scheck's witness also admitted that because two separate DNA labs collected blood from the same spot in the Bronco independently and both returned the same matches, that proves they weren't contaminates.

[20][21] M. L. Rantala wrote in OJ Unmasked that Scheck implied the evidence locker was in the PCR amplification room[22] so his contamination claim would be plausible but opined that he was being deceptive because he had toured the lab and knew that wasn't true.

[23] Petrocelli also noted in Triumph of Justice that Scheck's witness John Gerdes lied when he said that Collin Yamauchi admitted spilling Simpson's blood in the lab presumably so the defense could imply that contamination could have happened that way as well.

[citation needed] In Triumph of Justice: Closing the Book on the O. J. Simpson Saga, Petrocelli explains how he disproved all of Scheck's blood planting claims.

[46] Christopher Darden wrote in In Contempt that nearly all of Scheck's blood planting claims were originally made by Stephen Singular in his book proposal for Legacy of Deception: An Investigation of Mark Fuhrman and Racism in the L.A.P.D.

[48] The New York Times wrote that "Mr. Simpson's "dream team" has fostered public mistrust of defense lawyers in general because of their 'shotgun approach' of attempting to shoot down every scrap of evidence against Mr. Simpson with a barrage of alternative (i.e., conspiracy) explanations"[49] and in 2014, Scheck acknowledged that public perception of defense attorneys changed as a result of the trial.

Petrocelli wrote in Triumph of Justice that "Scheck prostituted his skills to get Simpson off with murder" and that he disproved all of his blood planting claims using photos and video that were available at the criminal trial.

He is Director of Clinical Education for the Trial Advocacy Program and the Center for the Study of Law and Ethics, and a former staff attorney at the Legal Aid Society of New York.