The final judgement found no proof of heresy but secluded him to the Dominican cloister of Santa Maria sopra Minerva where he died seven days later.
In 1530 he was denounced to the Inquisition as limiting the papal power and leaning to the opinions of Erasmus, but the process failed; he was made professor of philosophy and regent in theology (1533 to 1539).
After his return, in 1540, the Emperor Charles V offered him the See of Cuzco in Peru, but Carranza declined the appointment and continued performing his duties as lector of theology at Valladolid.
On this question, Carranza wrote and issued a treatise, Controversia de necessarii residentii personali episcoporum et aliorum inferiorum ecclesiæ pastorum Tridenti explicata.
[1] Carranza also had a share in drawing up the eleven articles proposed by the Spaniards, which treated the duty of episcopal residence and other questions of discipline relating to the office of a bishop.
In 1548 Charles asked him to accompany Prince Philip to Flanders as confessor, but Carranza declined the position; in 1549 he again refused the appointment of Bishop of the Canary Islands.
He sought to prevent the sale of Protestant books, preached frequently against what he considered as "the false doctrines", and made an inspection of the University of Oxford, from which, by his efforts, a number of professors were expelled.
After Charles V had abdicated the throne and was succeeded, in Spain, by Philip, Carranza returned, in 1557, to the Continent, and went to Flanders, where the new king had his principal residence at that time.
The See of Toledo falling vacant by the death of the Cardinal Archbishop Siliceo, 31 May 1557, the king decided upon Carranza as successor to the position.
Philip II persisted in his choice, so that at last Carranza yielded and was preconized by Pope Paul IV, 16 December 1557, as Archbishop of Toledo and, therefore, Primate of Spain.
A number of views suspected of heresy were found in the book, and the Grand Inquisitor Fernando de Valdés y Salas brought an action against the author.
Besides this work on the catechism, Carranza's manuscripts, expressions he had employed in sermons, and letters found in his possession, including one from Juan Valdés, the heretic, were taken as evidence against him.
Melchior Cano, the famous theologian, and Dominicus de Soto, both members of the same order as the archbishop, drew numerous propositions from the commentary which were open to ecclesiastical censure.
A Brief of Paul IV, dated 7 January 1559, had granted the Grand Inquisitor of Spain the power, for the space of two years, to investigate the conduct of all Spanish bishops; this measure was intended to counteract the threatening danger of the spread of Protestant doctrine.
With the permission, therefore, of King Philip II (26 June 1558) the grand inquisitor had the archbishop arrested at Torrelaguna, 22 August 1558, and brought a prisoner to Valladolid.
Pope Pius IV made repeated requests to Philip II in the matter, and was urged several times in 1562 and 1563 by the members of the Council of Trent, to bring the case of the Archbishop of Toledo before his court.
Previous to receiving the last sacraments he touchingly declared that he had been all his life a true adherent of the Catholic Faith, that he had never voluntarily understood and held the condemned propositions in a heretical sense, and that he submitted entirely to the judgment pronounced upon him.
He had borne the imprisonment of nearly seventeen years with patience and resignation According to J. P. Kirsch: Carranza's sorrowful fate was brought about, largely, by the intense desire to keep all Protestant influences out of Spain.
[6] Besides the Commentary, Carranza published a Summa Conciliorum et Pontificum a Petro usque Paulum III (Venice, 1546), which has often been re-published and enlarged by later editors.