Bartolomé de la Cueva y Toledo (24 August 1499 – 29 June 1562) was a Spanish Roman Catholic cardinal and bishop.

[1] As a young man, before he took Holy Orders, he had an illegitimate son, Bartolomé de la Cueva.

[1] Pope Paul III made him a cardinal priest in the consistory of 19 December 1544.

[1] Charles V was annoyed that Pedro Pacheco, Bishop of Pamplona was not elevated to the cardinalate and he forbade the three Spaniards made cardinals on 19 December 1544 from wearing the cardinalate habit until Bishop Pacheco was also made a cardinal the next year.

[1] On the vigil Pentecost, 8 June 1549, he was consecrated as a bishop in Rome by Cardinal Juan Álvarez de Toledo.