Bartolomeo Manfredi (baptised 25 August 1582 – 12 December 1622) was an Italian painter, a leading member of the Caravaggisti (followers of Michelangelo Merisi da Caravaggio) of the early 17th century.

Certainly the Bartolomeo Manfredi known to art history was a close follower of Caravaggio's innovatory style, with its enhanced chiaroscuro and insistence on naturalism, with a gift for story-telling through expression and body-language.

And of these Caravaggisti (followers of Caravaggio), Manfredi seems in turn to have been the most influential in transmitting the master's legacy to the next generation, particularly with painters from France and the Netherlands who came to Italy.

Manfredi was a successful artist, able to keep his own servant before he was thirty years old, "a man of distinguished appearance and fine behaviour" according to the biographer Giulio Mancini, although seldom sociable.

He built his career around easel paintings for private clients, and never pursued the public commissions upon which wider reputations were built, but his works were widely collected in the 17th century and he was considered Caravaggio's equal or even superior.