He was colonel of the Piedmontese army, in which he participates in the wars of the Italian resurgence.

Paralyzed from below waist by the blast of a grenade, he continued to participate in wheelchair battles pushed by his assistant.

Bartolomeo is the ancestor of the Line III of the Princes Ruspoli.

He was the grandfather of Donna Emanuella de Dampierre Ruspoli, Duchess of Segovia and Duchess of Anjou by her marriage to Infante Don Jaime, son of Alfonso XIII of Spain.

Emanuele is the founder of the third Ruspoli line: The Princes of Poggio-Suasa.