The Barzillai Weeks House is a historic house located at 313 High Street in the West Barnstable section of Barnstable, Massachusetts.

The 1+1⁄2-story Cape style house was built in 1799 by Barzillai Weeks.

The house was the center of a local farm for over 150 years, most of them under the ownership of Weeks' descendants.

The house has well-preserved Federal styling, most prominent in the five-pane transom window over the main entrance.

[2] The house was listed on the National Register of Historic Places on March 13, 1987.