After the outbreak of the Syrian revolution, Jaafari was the public face of the Assad regime amidst crackdowns on protestors.

[8] Jaafari dismissed the conclusions of the 2016 report of the OPCW-UN Joint Investigative Mechanism that determined the Syrian Air Force use chlorine in separate attacks in Talmanes and Sarmin.

[12] Jaafari called a United Nations General Assembly vote on 22 December 2016 to establish a special team to collect, consolidate, preserve, and analyze evidence and to prepare cases on war crimes and human rights abuses "a flagrant interference in the internal affairs of a UN member state.

"[13] After the UNSC adopted Resolution 2401 in 2018 that called for a ceasefire in Syria for 30 days amidst the siege of Eastern Ghouta, Jaafari stated that the regime would continue to practice "a sovereign right of self-defense" and would go after what it deemed were terrorist groups.

Jaafari stated at the 2014 Geneva II Conference on Syria that stopping terrorism, not power-sharing, was the priority for talks between the Syrian government and opposition representatives, a stance the New York Times indicated would promise more confrontation.

[17] After the fall of the Assad regime in December 2024, Jaafari's sudden support for the political change was covered in news media.

[5] Walters expressed regret for hiring Jaafari and helping her obtain an internship and admission to the School of International and Public Affairs at Columbia University.