Basilio Pompili (16 April 1858 – 5 May 1931) was an Italian Catholic prelate who served as Vicar General of Rome from 1913 until his death.

Basilio Pompili was born in Spoleto, and studied at the Pontifical Roman Seminary before being ordained to the priesthood on 5 December 1886.

During his time at the Roman Rota, Pompili sat at the sixth trial for the annulment of Paul Ernest Boniface and Anna Gould.

Before becoming a bishop, Pompili was created cardinal deacon of Santa Maria in Domnica by Pope Pius X in the consistory of 27 November 1911.

He received his episcopal consecration on the following 11 May from Cardinal Antonio Agliardi, with Archbishop Donato Sbarretti and Bishop Americo Bevilacqua serving as co-consecrators, in the church of S. Vincenzo de' Paoli alla Bocca della Verità.