The building is a masonry structure of New Jersey brownstone, and decorative elements are made of blue Ohio sandstone.

[2] A flat coffered ceiling that covers the auditorium is constructed of wooden beams and painted blue with gold leaf.

[2] On the chapel's upper pier walls appear the symbols of the Greek Cross and the Shield of the Trinity, emphasizing Yale's conservative Trinitarianist Congregational religious heritage.

The Apse Memorial Windows were designed by the architect Russell Sturgis and installed by Slack, Booth & Co. of Orange, New Jersey in 1876.

These include George Berkeley, Jonathan Edwards, Benjamin Silliman, James Luce Kingsley, Chauncey A. Goodrich, Nathaniel W. Taylor, Eleazar Thompson Fitch, Denison Olmstead, Edward C. Herrick, William A. Larned, Anthony D. Stanley, and James Hadley.