The following year, the battery fought at Cape Girardeau, Chalk Bluff, Vicksburg, the Expedition to Morganza, Brownsville, and Fort Esperanza.

Later, the battery was attached to the Department of the West and took part in Major General John C. Frémont's advance to Springfield, Missouri.

[3] The cavalry vanguard dispersed a Confederate force in the action at Springfield on 25 October 1861, while Frémont's main army arrived two days later.

On November 7, Hunter ordered a retreat in three columns, including one under Brigadier General John Pope to Sedalia.

It was assigned to the District of Southwest Missouri from June to October 1862, when it was transferred to the 2nd Brigade, 3rd Division, within the Army of the Frontier.

[6] On 28 October, Schofield with the 2nd and 3rd Divisions skirmished with Major General Thomas C. Hindman's Confederate forces.

[10] Between 3 and 7 December, the 2nd and 3rd Divisions under Brigadier General Francis J. Herron made a remarkable forced march to Blunt's assistance, covering 105 and 120 mi (169 and 193 km) respectively.

[11] During the Battle of Prairie Grove, Battery E under Lieutenant Foust was attached to Colonel William W. Orme's 2nd Brigade in Herron's 3rd Division.

[12] At 10:00 am on 7 December 1862, Herron found his two divisions blocked by Hindman's army on the Prairie Grove hill.

He detached Lieutenant Edward's 2-gun section of Battery E and sent it forward with the purpose of getting the Confederate artillery to reveal its positions.

Battery E galloped forward, then swerved to the left to unlimber on a knoll to the east of the Fayetteville Road.

Confederate counterbattery fire caused few Union casualties, though a near-miss round shot knocked Orme off his horse.

Foust's battery was "particularly effective" because it obtained enfilade fire on the Confederate lines from its forward position.

Herron complimented his gunners, "Never was there more real courage and pluck displayed, and more downright hard fighting done".

The rallied Union foot soldiers and the gunners drove back their opponents with heavy fire.

[17] At Van Buren, the Federals burned five steamboats and tons of supplies needed by the Confederate army.

[3] The Federal troops led by Brigadier General John McNeil drove off Marmaduke's attack.

[3] At some time in the early spring, Captain Cole resumed command of Battery E and the unit temporarily added a third 3.5-inch Blakely rifle.

During the Vicksburg siege, Battery E under Captain Cole was part of Brigadier General William Vandever's 1st Brigade, Herron's division, Major General James B. McPherson's XVII Corps, Army of the Tennessee according to Battles and Leaders.

[3] Batteries B, E, and F, 1st Missouri Light Artillery were assigned to Herron's 2nd Division, Major General Cadwallader C. Washburn's XIII Corps.

[3] In this action, a Confederate force led by Tom Green attacked and overwhelmed a Federal detachment, inflicting 515 casualties.

[24] Part of Battery E fought at Stirling's Plantation and suffered the following losses in enlisted men: three killed, three wounded, and 12 missing.

[27] On 16 November, 1,100 Federal troops seized Mustang Island and captured 98 Confederate soldiers and three heavy cannons.