While they will likely continue to play annually, they will not do so within the Big 5 unless both teams finish in the same position in their respective pods.

The schools also occasionally face each other in other sports, including lacrosse, women's basketball, and field hockey.

On March 11, 2014, Drexel and Penn faced each other in the first round of the 2014 NCAA Division I Men's Lacrosse Championship.

The teams earned automatic bids by winning each of their conference tournaments, and marked Drexel's first invitation to the national championship.

The game was played at Franklin Field, and the Dragons defeated the Quakers by score of 16–11 to advance to the tournament quarterfinals.