The Battle of Clark's Mill was fought on November 7, 1862, near Vera Cruz, Missouri, as part of the American Civil War.

Union Captain Hiram E. Barstow commanded a detachment at Clark's Mill near Vera Cruz, and heard rumors of Confederate depredations around Gainesville.

[2] The Missouri State Guard was mostly merged into the regular Confederate army after the battle, and both sides transferred troops out of the Ozarks region.

[4] Besides guerrilla warfare, Confederate Major General Thomas C. Hindman had led some of his forces into southwestern Missouri from Arkansas.

[5] While Hindman's regular Confederate troops withdrew in early October not long after the First Battle of Newtonia, a guerrilla presence remained in the Ozarks.

On the morning of November 7, Barstow sent twenty men to Gainesville in response to rumors of Confederate depredations there, while he personally led a similarly-sized force in the direction of Rockbridge.

[11] The local historian Danny Keller describes the action as an artillery duel that ended with the Confederates surrounding the Union position and cutting its line of retreat.

[14] With night falling, Burbridge sent a message under flag of truce offering Barstow surrender terms; the Union officer accepted.

[18] Following the battle, Barstow made his way to Marshfield,[12] while the Confederates moved on from the Clark's Mill area,[15] withdrawing up Bryant Creek.

[19] More troops from the 14th Missouri State Militia Cavalry[10] made a counterstroke the day after the battle, moving from Ozark into Douglas County, and then heading to Dubuque, Arkansas, killing or capturing about 30 Confederates along the way.