[42] On 17 October, the Syrian Army engaged ISIS on the east bank of the Euphrates and captured Al-Khasarat, Al-Kanamat, and Al-Matar, giving them control of all areas surrounding the ISIL-held parts of the city.

[citation needed] On 17 October, the Army captured three districts in Deir ez-Zor and advanced in three other areas,[44] bringing 90 percent of the city under their control.

[45] On 18 October, while operations were being conducted against ISIL forces on Saqr Island, Major General Issam Zahreddine was killed after his convoy hit a landmine.

[47] On 25 October, the Syrian Army broke through ISIL defenses in the northwest section of the Al-Harabisheh district, advancing 100 meters past the city stadium.

[52] On 31 October, Syrian Government forces had recaptured the districts of al-Kannamat and al-Rasafeh, as well as completely securing the Old Airport area, after taking the municipal stadium on the previous day.

On the next day, ISIL's defense lines collapsed[56] as the Tiger forces and Republican guard units made rapid advances in the central parts of the city, capturing Deir ez-Zor's largest district,[57] Hamidiyah.

[60] By midnight, the Sheikh Yassin, Ardhi and Rashdiyah neighborhoods were captured,[61][60] leaving only the al-Hawiqa district under jihadist control,[6] with around 100 militants confined there.

[63] By 17 November, the last ISIL fighters on the island had surrendered, and the Syrian Army regained control of all territory surrounding Deir ez Zor city.