The capture and execution of Conradin several months after the battle also marked the fall of the family from the Imperial and Sicilian thrones, leading to the new chapter of Angevin domination in Southern Italy.

Bolstered by papal resources, which included a crusading tithe granted to combat the "infidel" Hohenstaufen, Charles entered Italy in 1265 and defeated and killed Manfred the next year at the Battle of Benevento, and began to establish himself as King of Sicily.

After Benevento, Clement IV continued the papal policy of employing Charles to resist the power of the Ghibellines, although with this support was the fear that the Angevins themselves would, like the Hohenstaufen before them, attempt to dominate northern as well as southern Italy and thus menace the temporal power of the Holy See, despite explicit promises by Charles that he would not lay claim to northern Italy.

[2] After considerable maneuvering, Conradin's army, which enjoyed numerical superiority, confronted that of Charles of Anjou on the Palentine Plains outside the town of Tagliacozzo (more precisely, near Scurcola Marsicana).

This third division was hidden behind a hill by Charles at Valery's advice, in order to constitute a tactical surprise against the numerically superior Hohenstaufen forces.