During the 1967 Six Day War, Zionist troops ethnically cleansed[2][3][4][5] Bayt Nuba and replaced it with the Jewish-only settlement of Mevo Horon.

[11] 5th century Christian scholar, Eusebius of Caesarea, mentioned the village in his Onomasticon, under the name Beth Annabam and situated it at a distance of 8 Roman miles from Lydda.

[16] Writing in the 13th century during the time of Mamluk rule over Palestine, Yaqut al-Hamawi, the Syrian geographer, noted of Bayt Nuba, that it was, "A small town in the neighbourhood of Filastin (Ar Ramlah).

"[9] A road from Ramla to Jerusalem that passed through Bayt Nuba, al-Qubeiba, and Nabi Samwil was the preferred route for Christian pilgrims to the Holy Land at the time.

He noted that conventional wisdom among the locals of his time held that they are named for Hebrew Bible prophets that were thought to have resided there in antiquity.

[19]The waqf custodian of the mosque in Bayt Nuba (and 'Allar) in 1810 was appointed by the Ottoman imperial authorities, and hailed from the Jerusalem family of notables, the Dajanis.

[21] Edward Robinson and Eli Smith visited Beit Nubah in 1838[22] and 1852,[23] and identified it as the Nobe mentioned by Jerome and considered by some of their contemporaries to be Bethannaba.

Located 2 miles (3.2 km) behind the front line, it was subject to a skirmish attack launched by Israeli forces in Operation Yoram on the night of June 8, 1948.

Many were prompted many to leave the area to seek livelihoods in Jordan, the Persian Gulf, South America or elsewhere due to violence between villagers and Israeli troops and the loss of access to farmlands.

The built up area of Bayt Nuba was destroyed in military engineered explosions after the war's end, an act witnessed by some of the former residents who had fled nearby hills.