The station is located on HaHaroshet Street and is connected to the Ben-Gurion University of the Negev by Mexico Bridge, a covered pedestrian walkway.

Another covered pedestrian bridge from the station leads to the technology office park located across the rail yard to the north.

The station complex also includes a large rail yard and a rolling stock maintenance depot.

After the closure of the old Turkish station and railroad south of the town in 1927, the Railway to Beersheba mainly served the phosphate and other mineral industries in the Negev.

In 2002, it was decided to move the passenger terminal at Be'er Sheva North 350 meters northwards to a new building nearby the university and an additional island platform was built.