Becaplermin, sold under the brand name Regranex, is a cicatrizant, available as a topical gel.

Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers.

[3] Pharmacoeconomic studies reinforce the cost effectiveness of becaplermin as an adjunct to good wound care.

[4] The amount of becaplermin to be applied will vary depending upon the size of the ulcer area.

[6] A boxed warning has been added to the US FDA prescription label to describe an increase rate of death from cancer when three or more tubes are used.