Pizzi credits her father, who ran competitively for the University of Massachusetts, for her running inspiration.

She graduated Belmont High School in 1998, and Mars Hill College in 2002, competing in track and field and cross country running in both institutions.

[2][10] Pizzi works two jobs, owning a day care and managing an ice cream parlor.

She was a single mother of a young daughter (she continued to run while pregnant, until 2 days before giving birth).

Only one American, Timothy Durbin, and only one woman, Marianna Zaikova of Finland, had completed the series of seven marathons on seven continents (Union Glacier, Antarctica; Punta Arenas, Chile; Miami, Florida; Madrid, Spain; Marrakesh, Morocco; Dubai, United Arab Emirates; and Sydney, Australia) in seven consecutive days.

Cool ice wraps, and Lyon-Waugh Auto group, a local car dealership, together covered 75% of the cost.

[21][22] On the first marathon, January 23, on a glacier in Antarctica, the sub-zero temperatures made Pizzi's iPod freeze and burst.

[11] In the North American marathon, in Miami, Pizzi was watched by friends, including the owner of the ice cream shop she manages, and her running coach from Mars Hill.

[14][28] To overcome the pain, she thought of New England Patriots quarterback Tom Brady, and his quote "I didn't come this far to just come this far.

[28] By the time her plane landed in Sydney for the final marathon, her groin was black and blue and swollen to the size of a softball.

[43] On April 17, 2016, the Boston Red Sox let her throw out the ceremonial first pitch, but before she did so, her boyfriend of five years made her the first woman proposed to on the Fenway Park pitcher's mound; Pizzi accepted.

[46][47] She injured her calf, and received deep tissue massage from Tom Brady's TB12 sports therapy center for two months, while preparing to run the World Marathon challenge again.

[51][47] She won the women's races in Novolazarevskaya Station, Antarctica; Cape Town, South Africa; Perth, Australia; Dubai, United Arab Emirates; and Lisbon, Portugal on consecutive days on January 30 through February 3.

She said Miami was her most memorable race; she had her telephone stolen with all her photos, but that was made up for by having her husband and family there to cheer her on.

She crossed the last 100 yards and the finish line running alongside her daughter, and the race director Richard Donovan gave each a gold medal.

[57] On May 13, 2023, Pizzi, with Chára encouraging her, ran her first ultramarathon, the Watuppa 50 kilometer race, in Fall River, Massachusetts.