The Belgian railway line 59 is a railway line in Belgium connecting Antwerp with Ghent.

Until 1970, the eastern terminus of the railway was a station on the left bank of the river Scheldt, opposite the city centre of Antwerp.

Since 1970, the railway is connected to Antwerp central station by a rail tunnel under the Scheldt.

The total length of the line between Antwerpen-Berchem and Gent-Dampoort (the section between Gent-Dampoort and Gent-Sint-Pieters is part of line 58 Ghent – Eeklo) is 55.8 km.

The main interchange stations on line 59 are: This European rail transport related article is a stub.