The series was based on a show of the same title that Gleib had performed for four years while he attended college at the University of California, San Diego.

[8] Gleib was billed as one of "the six comedians who could be comedy's next big things" and part of "a bumper crop of brilliant new-alt comics" by Esquire.

He is known for covering a wide range of topics in his act as well as his improvisational skills, often making up large sections of his performance based on interactions with the crowd.

[11] He has been a frequent guest on KPCC (Southern California's NPR affiliate) on the Patt Morrison Program, bringing his comedic spin to political issues.

The film also featured Charlie Murphy, Daniel Franceze, Derek Waters, Jon Bernthal, and Nikki Griffin.

Gleib is also the voice of Marshall the Sloth in Ice Age: Continental Drift (2012), one of the stars of Kevin Smith's Jay & Silent Bob's Super Groovy Cartoon Movie!

His voices have also appeared in Phineas and Ferb and the YouTube series The Melvin Bros.[12] In addition, Gleib has performed on The Late Late Show on CBS, at both the Vancouver Comedy Festival and Laughing Matters Festival in the Netherlands, hosted several podcasts for Current TV, and wrote for the "Radio Music Awards" for ABC in 2002.

[26] On August 21, 2019, at the annual AFL-CIO convention at Prairie Meadows Hotel in Altoona, Gleib was the final speaker out of all 2020 Democratic candidates who spoke.

[32] Comedians including Jackie Fabulous, Sean Patton, Jay Jurden, Josh Johnson, Nikki Glaser, and Christian Finnegan all performed at Nowhere during the first year of operation.