He played for the Wests Tigers and the Penrith Panthers in the NRL, and the Salford Red Devils and the Warrington Wolves in the Super League.

He undertook a scholarship with Wests Tigers at Keebra Park High School and was a member of the team that won the 2009 Arrive Alive Cup.

He also signed an extension to stay with the club until the end of 2015, with coach Tim Sheens saying, "There is no doubt Ben has enormous talent and potential.

On 29 June 2023, Murdoch-Masila played his 100th game against the Cronulla-Sutherland Sharks with the club losing 16–52 in their biggest ever loss against there arch rivals.

[21] On 17 October 2015, Murdoch-Masila played for Tonga in their Asia-Pacific Qualifier match against the Cook Islands for the 2017 Rugby League World Cup.

He played in every match of Tonga's historic charge to the semi-finals of the 2017 Rugby League World Cup, and set up a vital try in their shock win over New Zealand in the pool stage of the tournament.