Special appearances include Coolio as Kwanzaa-bot, Al Gore as himself, Mark Hamill as Chanukah Zombie, Tom Kenny as Fry's older brother Yancy, and Sarah Silverman returning as Fry's ex-girlfriend Michelle (having previously voiced the role in "The Cryonic Woman").

Three alien scammers—Nudar, Fleb and Schlump—obtain the crew's personal information and infect Bender with an obedience virus, allowing them to seize control of Planet Express.

The scammers have Bender use the code to steal valuable objects from Earth's past and a doomsday device from Professor Farnsworth, storing them in a cave beneath the Planet Express building.

Another Bender from "way at the end" appears, opens Fry's cryogenic tube and puts the tattoo on his butt.

The Fry duplicate spent the years before Bender's attack working at Panucci's Pizzeria, then at an aquarium caring for Leelu, an orphaned narwhal.

Hermes has his brain wired into the ship's battle computer, allowing him to destroy the scammers' fleet and win back his wife.

Bender removes Lars' tattoo and travels to 2000 to place it on Fry in the cryogenic tube so that the events that transpired "make any sense at all".

Upon returning, Bender explains that he convinced all the duplicates of himself from his stealing sprees to stay with him, instead of leaving "when they were logically supposed to."

The Bender duplicates explode, causing a tear in the fabric of space, leading into the events of The Beast with a Billion Backs.

[1] The film was broken into four separate episodes which served as the first part of Futurama's fifth season, followed by The Beast with a Billion Backs, Bender's Game, and Into the Wild Green Yonder.

The TV movie was screened in the United Kingdom on Sky1, which started airing Bender's Big Score on October 26, 2008.

The three additional opening captions are: "Watch, Rinse, Repeat", "Apply directly to the foreclaw" (a reference to HeadOn), and "Last Known Transmission of the Hubble Telescope."

[11] The movie received an "A" rating in a review at UGO, calling its two musical numbers "hilarious", and the overall quality on par with that of the show's original run.

[12] Dan Iverson of IGN gave the movie an 8 out of 10, stating that "it is easy to recommend Bender's Big Score to fans of the series and those new to the show alike".

[13] Torgo's Executive Powder is an elaborate running gag throughout the film in retaliation against the Fox Network for its alleged mishandling and eventual cancellation of Futurama.

[14] The product is said to have "a million and one uses" and consists of ground-up executives, including those of the film's thinly veiled Fox Network parody (the Box Network), and makes repeated appearances due to its miraculous utility in such diverse tasks as seasoning, surgery, delousing, feeding heads in jars, cosmetics, bomb disposal, artillery, and the care of head transplant patients.

When the film was aired on Comedy Central, a fake commercial was shown preceding the first break in which a woman dumps some of the powder in a toilet.