[1] After eleven years of negotiations which resulted in a renewed accord between the Empire and Genoa, Benedetto re-appeared in Constantinople with his brother Manuele in 1275.
This was an extremely lucrative business, especially after Manuele acquired a near-monopoly after persuading Michael VIII to prohibit the import of alum from the Black Sea, even though this trade was also in the hands of Genoese merchants.
[2] As an agent of the emperor, Benedetto acted as an ambassador to Peter III of Aragon in 1280–1282, and took part in the negotiations that led to the Byzantine–Aragonese alliance and the outbreak of the War of the Sicilian Vespers that ended the threat of an invasion of Byzantium by Charles I of Anjou.
In 1302, Zaccaria was named admiral by Philip of France, in which capacity he conquered the island of Chios (1304), which had hitherto been in the hands of Moslem corsairs.
In 1304, he also occupied Samos and Cos, which were almost completely depopulated, and the emperor conceded him sovereignty over those islands and Chios for two years, under Byzantine suzerainty.