During the middle of the 16th century, the city belonged to one of the mightiest dynasties of the Great Duchy of Lithuania - the Sapieha Family, who controlled many other territories in Central Belarus.

In 1641 the Duke Kazimierz Leon Sapieha built a wooden Catholic Church which became one of the central attractions of the town.

The most logical version by berezino.net is that Sapieha owned the town until partition took place in 1793, and Berezino was granted by Empress Ekaterina II to Count Ludwik Tyszkiewicz.

She tried to revive the Berezino region economically by starting a carpet factory in Horenichi village, but the investment didn't survive for long.

The town was under French/Polish command in 1812 during Napoleon's Eastern Campaign, where his failed advance on Moscow was defeated fully by the forces of General Barclay de Tolly in early 1813.

The town was in Potocki (pronounced Pototski) family possession well until June 1920, when the Bolshevik Red Army attacked Poland and subsequent peace treaty changed the Soviet-Polish borders as the place become part of Soviet territory.

It is considered the brilliant investment by Potocki family---to date, the most profitable enterprise, supplying much of the town budget and tax revenues.

During that time, mass industrialisation took place, and the position of the river port allowed a development of shipbuilding, wheel, textile and liquor factories, as well as smaller workshops for automobiles and wood fabrics.

68 buildings are deemed as architectural heritage, including the famous House of Duke Pototsky, which is very much neglected by the government.

The original wooden Roman Catholic Church, founded by L. Sapieha in 1641, and upgraded by countess Anna Potocka-Wasowicz in 1802, burnt down in a huge town fire in 1914.